Regulation of Kv4.3 voltage-dependent gating kinetics by KChIP2 isoforms

Coupling of Voltage-dependent Gating

I N T R O D U C T I O N Many K§ channels are inhibited by Ba ions. In the cases for which careful mechanistic studies have been carr ied out (Armstrong and Taylor , 1980; Eaton and Brodwick, 1980; Armst rong et al., 1982; Vergara and Latorre , 1983), the evidence argues that the Ba ion acts via a simple blocking scheme; it enters the conduct ion pathway o f the K § channel, where it binds tight...

Voltage-Dependent Gating of hERG Potassium Channels

The mechanisms by which voltage-gated channels sense changes in membrane voltage and energetically couple this with opening of the ion conducting pore has been the source of significant interest. In voltage-gated potassium (Kv) channels, much of our knowledge in this area comes from Shaker-type channels, for which voltage-dependent gating is quite rapid. In these channels, activation and deacti...

Gating kinetics of four classes of voltage-dependent K+ channels in pheochromocytoma cells

Clonal pheochromocytoma (PC-12) cells have four different types of voltage-dependent K+ channels whose activation does not require high concentrations of Ca++ on the cytoplasmic side of the membrane (Hoshi, T., and R. W. Aldrich, 1988, Journal of General Physiology, 91:73-106). The durations of open and closed events of these four different types of voltage-dependent K+ channels were measured u...

Kramers' diffusion theory applied to gating kinetics of voltage-dependent ion channels.

Kramers' diffusion theory of reaction rates in the condensed phase is considered as an alternative to the traditional discrete-state Markov (DSM) model in describing ion channel gating current kinetics. Diffusion theory can be expected to be particularly relevant in describing high-frequency (>100 kHz) events in channel activation. The generalized voltage sensor of a voltage-dependent ion chann...

Voltage-dependent ion channels and their gating.